Enzyme Toxicology

Enzyme Toxicology is unremarkable, except the potential irritating effects usually associated with some proteases at high concentrations, and the allergic effects of enzymes. Like anything one is exposed to, the dose makes the poison; thus, with certain enzymes, a sufficient excess in exposure can lead to irritation. Enzymes are like the majority of food proteins so that oral exposure to the gut is entirely without effect, except perhaps at very high, unrealistic, exposure levels 

Enzymes have been evaluated for genotoxic effects Nevertheless, enzymes are not mutagenic in the standard screening assays used in genetic toxicology, specifically the Ames test, and are not clastogenic in chromosome aberration tests. Repeated exposure studies on a number of enzymes have been completed. Most often this has been done in relation to enzymes to be used in foodstuffs and so exposure has been carried out via the oral route. 

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